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Published on: July 3, 2020
Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation
Mi Ran Byun1, A Rum Kim, Jun-Ha Hwang
1School of Life Science and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.
Abstract:
Osteoporosis arises from an imbalance between osteoblastic bone formation and osteoclastic bone resorption. In this study, we screened molecules from marine natural products that stimulate osteoblast differentiation. We found that phorbaketal A significantly stimulates osteoblast differentiation in mesenchymal cells. Increased interaction of TAZ and Runx2 stimulated phorbaketal A-induced expression of osteoblastic marker genes. The activation of ERK was important for the stimulation of differentiation because an inhibitor of ERK blocked phorbaketal A-induced osteogenic differentiation. Taken together, the results showed that phorbaketal A stimulates TAZ-mediated osteoblast differentiation through the activation of ERK.
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