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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

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Related Experiment Video

Updated: May 22, 2026

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization
07:34

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization

Published on: November 17, 2023

A spotlight from prostate cancer.

Harvey R Herschman1, Johannes Czernin

  • 1Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA. hherschman@mednet.ucla.edu

Cancer Discovery
|May 12, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces a novel imaging method using a labeled antibody to visualize prostate-specific antigen (PSA) in prostate cancer. This technique allows for better monitoring of cancer progression and treatment response.

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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

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Last Updated: May 22, 2026

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization
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Published on: November 17, 2023

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
07:01

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

Area of Science:

  • Oncology
  • Immunology
  • Radiochemistry

Background:

  • Serum prostate-specific antigen (PSA) is a key biomarker for prostate cancer management.
  • Interpreting serum PSA levels for clinical decision-making can be challenging.
  • Current methods lack noninvasive imaging capabilities for direct PSA assessment in vivo.

Purpose of the Study:

  • To develop and evaluate a novel noninvasive imaging technique for prostate cancer.
  • To utilize a positron-emitting labeled monoclonal antibody targeting a unique PSA epitope.
  • To assess androgen-stimulated PSA expression and androgen therapy response in vivo.

Main Methods:

  • Development of a positron-emitting labeled monoclonal antibody against a specific PSA epitope.
  • Noninvasive imaging of PSA-positive prostate cancer xenografts in vivo.
  • Quantification of PSA expression changes in response to androgen stimulation and therapy.

Main Results:

  • Successful noninvasive imaging of prostate cancer xenografts was achieved.
  • The method demonstrated the ability to measure androgen-stimulated PSA expression.
  • The technique effectively monitored PSA decreases in response to androgen therapy.

Conclusions:

  • This novel antibody-based imaging approach offers a noninvasive tool for prostate cancer monitoring.
  • It provides a method to directly assess PSA dynamics related to androgen signaling.
  • This technique holds potential for improved interpretation of PSA levels in clinical settings.