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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale
Steven P Hanlon1, Andrea Camattari, Sandra Abad
1F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.
Chemical Communications (Cambridge, England)
|May 12, 2012
Abstract:
A panel of human flavin monooxygenases were heterologously expressed in E. coli to obtain ready-to-use biocatalysts for the in vitro preparation of human drug metabolites. Moclobemide-N-oxide (65 mg) was the first high-priced metabolite prepared with recombinant hFMO3 on the multi-milligram scale.
