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Updated: May 22, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Relation between indices of end-organ damage and mean platelet volume in hypertensive patients

Serkan Bulur1, Halil Ibrahim Önder, Yusuf Aslantas

  • 1Duzce Medical School, Department of Cardiology, Düzce University, Konuralp, Düzce, Turkey. drserkanbulur@yahoo.com

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|May 12, 2012
PubMed

Insights

Mean platelet volume (MPV) did not correlate with markers of end-organ damage in hypertension patients. This study found no association between MPV levels and left-ventricular mass index, albuminuria, or retinopathy.

Area of Science:

  • Cardiology
  • Nephrology
  • Ophthalmology

Background:

  • Mean platelet volume (MPV) is an independent risk factor for hypertension.
  • Hypertensive end-organ damage significantly impacts patient prognosis.
  • Investigating MPV's role in subclinical damage is crucial for understanding hypertension progression.

Purpose of the Study:

  • To examine the association between mean platelet volume (MPV) and subclinical end-organ damage in hypertensive individuals.
  • To determine if MPV levels correlate with left-ventricular mass index (LVMI), albuminuria, or retinopathy in hypertension.

Main Methods:

  • A cohort of 116 hypertensive patients (mean age 53 ± 11 years) was analyzed.
  • MPV levels were measured and compared against LVMI, urinary albumin-to-creatinine ratio, and retinopathy grading.
  • Statistical analysis, including correlation coefficients (r) and P-values, was performed.

Main Results:

  • No significant correlation was found between MPV and left-ventricular mass index (r = 0.145; P = 0.14).
  • MPV showed no association with albuminuria (r = 0.009; P = 0.93).
  • Similar MPV levels were observed in patients with grade I and grade II retinopathy (P = 0.28).

Conclusions:

  • This study found no correlation between mean platelet volume (MPV) and key markers of end-organ damage in hypertensive patients.
  • MPV does not appear to be a reliable indicator of subclinical organ damage in this hypertensive cohort.
  • Further research may be needed to explore other potential biomarkers or mechanisms in hypertensive end-organ damage.

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