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Updated: Aug 5, 2026
10:02
Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
[Ciprofloxacin: intraocular absorption in man]
Bulletin Des Societes D'Ophtalmologie De France
|August 1, 1990
Summary
Ciprofloxacin penetrates the human aqueous humor, reaching concentrations effective against bacterial endophthalmitis pathogens. Further research is needed to confirm its safety and efficacy for treatment.
Area of Science:
- Ophthalmology
- Pharmacokinetics
- Infectious Diseases
Background:
- Endophthalmitis is a serious intraocular infection requiring effective antibiotic treatment.
- Achieving adequate intraocular antibiotic concentrations is crucial for therapeutic success.
Purpose of the Study:
- To investigate the intraocular penetration of Ciprofloxacin after oral administration in humans.
- To determine if Ciprofloxacin concentrations in the aqueous humor exceed the minimum inhibitory concentration (MIC) for common bacterial pathogens.
Main Methods:
- A study involving 30 patients receiving a single 1000 mg oral dose of Ciprofloxacin.
- Aqueous humor samples were collected from 1.30 to 4 hours post-dose.
- Samples were analyzed using a microbiological assay to quantify Ciprofloxacin levels.
Main Results:
- Average Ciprofloxacin concentration in the aqueous humor was 0.73 mg/L, representing 33% of serum levels.
- Therapeutic concentrations were achieved within 1.30 to 4 hours after dosing.
- Achieved concentrations were above the MIC for many bacterial agents implicated in endophthalmitis.
Conclusions:
- Oral Ciprofloxacin demonstrates significant intraocular penetration into the anterior chamber.
- The achieved concentrations suggest potential efficacy in treating bacterial endophthalmitis.
- Further clinical trials are necessary to establish the safety and definitive efficacy of Ciprofloxacin for endophthalmitis treatment.
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