Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ciprofloxacin: intraocular absorption in man].

A Bron1, D Talon, T Cellier

  • 1Service Ophtalmologie, Hôpital Jean Minjoz, Besançon.

Bulletin Des Societes D'Ophtalmologie De France
|August 1, 1990
PubMed
Summary

Ciprofloxacin penetrates the human aqueous humor, reaching concentrations effective against bacterial endophthalmitis pathogens. Further research is needed to confirm its safety and efficacy for treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Medical and surgical treatment of acute postoperative endophthalmitis].

Journal francais d'ophtalmologie·2024
Same author

[Tribute to Dr Mohammed Ezzouhairi].

Journal francais d'ophtalmologie·2024
Same author

[Ultra-widefield imaging of fundus albipunctatus discovered in a 30-year-old woman seen for night blindness].

Journal francais d'ophtalmologie·2023
Same author

[Proptosis secondary to infantile myofibromatosis in a newborn: role of the ophthalmologist from diagnosis to treatment].

Journal francais d'ophtalmologie·2022
Same author

[Corneal toxicity of mirvetuximab soravtansine: A case report].

Journal francais d'ophtalmologie·2022
Same author

[Management of ocular toxoplasmosis in France: Results of a modified Delphi study].

Journal francais d'ophtalmologie·2022

Area of Science:

  • Ophthalmology
  • Pharmacokinetics
  • Infectious Diseases

Background:

  • Endophthalmitis is a serious intraocular infection requiring effective antibiotic treatment.
  • Achieving adequate intraocular antibiotic concentrations is crucial for therapeutic success.

Purpose of the Study:

  • To investigate the intraocular penetration of Ciprofloxacin after oral administration in humans.
  • To determine if Ciprofloxacin concentrations in the aqueous humor exceed the minimum inhibitory concentration (MIC) for common bacterial pathogens.

Main Methods:

  • A study involving 30 patients receiving a single 1000 mg oral dose of Ciprofloxacin.
  • Aqueous humor samples were collected from 1.30 to 4 hours post-dose.
  • Samples were analyzed using a microbiological assay to quantify Ciprofloxacin levels.

Related Experiment Videos

Main Results:

  • Average Ciprofloxacin concentration in the aqueous humor was 0.73 mg/L, representing 33% of serum levels.
  • Therapeutic concentrations were achieved within 1.30 to 4 hours after dosing.
  • Achieved concentrations were above the MIC for many bacterial agents implicated in endophthalmitis.

Conclusions:

  • Oral Ciprofloxacin demonstrates significant intraocular penetration into the anterior chamber.
  • The achieved concentrations suggest potential efficacy in treating bacterial endophthalmitis.
  • Further clinical trials are necessary to establish the safety and definitive efficacy of Ciprofloxacin for endophthalmitis treatment.