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Updated: Aug 11, 2026
10:09
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
Published on: January 7, 2019
Oncogenes and cancer: clinical applications
1Department of Laboratory Hematology, The Cleveland Clinic Foundation, Ohio 44195.
Cleveland Clinic Journal of Medicine
|November 1, 1990
Summary
Oncogenes and anti-oncogenes are key in cancer development. Understanding their abnormalities, like bcr-abl in leukemia or retinoblastoma genes, aids diagnosis and treatment.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Proto-oncogenes regulate cell growth; aberrant forms (oncogenes) drive tumor formation.
- Anti-oncogenes normally inhibit cell growth; mutations lead to tumorigenesis.
- Abnormalities in these genes are linked to various cancers.
Purpose of the Study:
- To review the role of oncogene and anti-oncogene abnormalities in cancer.
- To highlight clinical applications of identifying these genetic alterations.
Main Methods:
- Review of scientific literature on oncogenes and anti-oncogenes.
- Discussion of specific gene abnormalities and their clinical relevance.
Main Results:
- Oncogene and anti-oncogene mutations are implicated in diverse tumor types.
- The bcr-abl gene rearrangement in leukemia has diagnostic and prognostic value.
- Molecular analysis of anti-oncogenes, like in retinoblastoma, aids disease differentiation and risk prediction.
Conclusions:
- Characterizing oncogene and anti-oncogene abnormalities offers significant clinical utility.
- Molecular diagnostics based on these genes improve cancer management and hereditary risk assessment.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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