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Association between serum homocysteine concentration with coronary artery disease in Iranian patients
Ahmad Mirdamadi1, Hamid Farzamnia, Pooyan Varzandeh
1Assistant Professor, Department of Cardiology, School of Medicine, Najaf Abad Branch, Islamic Azad University, Isfahan, Iran.
Insights
High plasma homocysteine levels are linked to increased coronary artery disease (CAD) risk in the Iranian population. This study highlights homocysteine as a significant biomarker for CAD in this demographic.
Area of Science:
- Cardiovascular Medicine
- Biomarkers Research
- Epidemiology
Background:
- Growing recognition of novel biomarkers, such as homocysteine, in assessing coronary artery disease (CAD) risk.
- Observed geographical variations in plasma homocysteine concentrations necessitate population-specific studies.
- Paucity of research in Iran evaluating hyperhomocysteinemia as a CAD risk factor.
Purpose of the Study:
- To investigate the association between plasma total homocysteine (tHcy) concentration and CAD risk within the Iranian population.
- To address the gap in understanding homocysteine's role in cardiovascular health in Iran.
Main Methods:
- A case-control study design was employed.
- Forty-five patients with angiographically proven CAD were compared with 45 age- and gender-matched controls without CAD.
- Exclusion criteria included conventional CAD risk factors (diabetes, hypertension, etc.); plasma tHcy was measured via immunoturbidimetry.
Main Results:
- Patients with CAD exhibited significantly higher mean plasma tHcy levels compared to the control group (17.1±5.3 vs. 14.2±3.8, P=0.004).
- The difference in tHcy levels between the groups was statistically significant.
Conclusions:
- Elevated plasma homocysteine concentration is associated with an increased risk of CAD in the Iranian population.
- Plasma homocysteine emerges as a relevant biomarker for CAD risk assessment in this demographic.
Background:
The role of novel biomarkers like homocystein as a risk factor of coronary artery disease (CAD) is being increasingly recognized. Since there is a marked geographical variation in plasma homocystein concentration and because of importance of hyperhomocysteinemia as a CAD risk factor and due to the paucity of studies in Iran evaluating this risk factor in our population, we evaluated the association between plasma total homocysteine (tHcy) concentration and CAD risk in Iranian population.
Methods:
In a case-control study, we compared the level of tHcy of forty five patients of angiographically proven CAD with forty five subjects without CAD as control group matched for age and gender. The patients with diabetes, hypertension, thyroid dysfunction, chronic renal failure, hyperlipidemia and obesity and other conventional CAD risk factors were excluded from the study. Plasma tHcy was measured using immunoturbidimetry. The results were compared between groups using student t test.
Results:
CAD patients had significantly higher mean plasma tHcy than control group (17.1±5.3 versus 14.2±3.8, P= 0.004).
Conclusion:
This study denoted that high plasma homocysteine concentration was associated to CAD risk in Iranian people.
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