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Astragalus injection for hypertensive renal damage: a systematic review
1Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China.
Summary
Astragalus injection shows promise in protecting kidneys from hypertension-induced damage by reducing key markers like microalbuminuria. However, more high-quality studies are needed to confirm these findings for hypertensive renal damage patients.
Area of Science:
- Nephrology
- Pharmacology
- Traditional Chinese Medicine
Background:
- Hypertension frequently leads to renal damage.
- Traditional Chinese Medicine, such as astragalus injection, is explored for managing complications.
- Evaluating evidence-based efficacy is crucial for clinical application.
Purpose of the Study:
- To assess the effectiveness of astragalus injection in patients with hypertension-induced renal damage.
- To synthesize available evidence from randomized controlled trials.
Main Methods:
- Systematic search of multiple databases (MEDLINE, CNKI, VIP, CBM, CMCI) up to August 2011.
- Inclusion of randomized controlled trials comparing astragalus injection with placebo or with standard antihypertensive drugs.
- Data analysis followed Cochrane review standards.
Main Results:
- Five low-quality randomized trials with 429 patients were included.
- Astragalus injection significantly reduced beta-2-microglobulin (β(2)-MG) and microalbuminuria (mAlb) compared to placebo.
- It improved blood urea nitrogen (BUN) and creatinine clearance rate (Ccr) compared to prostaglandin.
- No adverse effects were reported.
Conclusions:
- Astragalus injection demonstrates potential protective effects on renal damage in hypertensive patients.
- Current evidence is limited by the low methodological quality of included trials.
- Further high-quality randomized controlled trials are necessary to establish definitive conclusions.
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