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Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Related Experiment Video

Updated: May 22, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Thoughts about cancer stem cells in solid tumors.

Caterina Am La Porta¹

¹Caterina AM La Porta, Department of Biomolecular Science and Biotechnology, University of Milan, via Celoria 26, 20133 Milan, Italy.

World Journal of Stem Cells

|May 12, 2012

Summary

Cancer stem cells (CSCs) drive tumor growth and resistance, posing a challenge for effective chemotherapy. Identifying CSCs and understanding their role is crucial for developing new cancer therapies.

Keywords:

Asymmetric self renewal Biomarkers Cancer stem cells Tumor

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Area of Science:

Oncology
Cancer Stem Cell Biology
Tumorigenesis

Background:

Chemotherapy efficacy is limited by tumor resistance, both intrinsic and acquired.
The cancer stem cell (CSC) theory offers a new perspective on tumor growth and therapeutic strategies.
Overcoming CSC resistance is critical for treating aggressive and metastatic cancers.

Purpose of the Study:

To review recent literature on CSCs in solid tumors (breast, prostate, brain, melanoma).
To highlight challenges in CSC identification, including marker selection and validation using mouse models.
To discuss the potential roles of aldehyde dehydrogenase and CXCR6 as biomarkers in CSCs and normal stem cells.

Main Methods:

Review of recent scientific papers on cancer stem cells in solid tumors.
Analysis of marker selection strategies for CSC identification and sorting.
Evaluation of mouse models for demonstrating CSC tumor-initiating capacity.

Main Results:

CSCs are implicated in tumor growth, resistance, and metastasis across various solid tumors.
Specific surface markers are essential for isolating and studying CSC subpopulations.
Aldehyde dehydrogenase and CXCR6 show potential as biomarkers in CSCs.

Conclusions:

Further investigation into the functional and biological properties of CSCs is necessary.
Developing diagnostic and prognostic tools for cancer development is a key challenge.
A multidisciplinary approach integrating mathematics, physics, and biology is recommended for advancing CSC research.