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Role of NKT Cells in the Pathogenesis of NAFLD
Kazuto Tajiri1, Yukihiro Shimizu
1The Third Department of Internal Medicine, Toyama University Hospital, Toyama, Toyama 930-0194, Japan.
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and shows various inflammatory changes in the liver. Among those inflammatory cells, natural killer T (NKT) cells are found to have a critical role during the disease progression. NKT cells may have a protective role at the early stage with simple steatosis through modification of insulin resistance, whereas they act as a progression factor at the advanced stage with fibrosis. Those processes are thought to depend on interaction between NKT cells and CD1d molecule in the liver.
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