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Resistin in idiopathic inflammatory myopathies
Mária Filková1, Hana Hulejová, Klára Kuncová
1Institute of Rheumatology, Department of Experimental Rheumatology of the 1st Faculty of Medicine, Charles University in Prague, Na Slupi 4, Prague 2, 128 50, Czech Republic.
Arthritis Research & Therapy
|May 15, 2012
Summary
Higher serum resistin levels and muscle resistin expression are linked to increased inflammation and disease activity in inflammatory myopathies. Resistin may play a role in the development of these conditions.
Area of Science:
- Immunology
- Rheumatology
- Molecular Biology
Background:
- Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterized by chronic muscle inflammation.
- Resistin, an adipokine, has been implicated in inflammatory processes, but its role in IIM is not fully understood.
Purpose of the Study:
- To compare serum resistin levels and local muscle expression in IIM patients versus controls.
- To investigate the relationship between resistin, inflammation, and disease activity in IIM.
Main Methods:
- Serum resistin levels were measured in 42 IIM patients and 27 healthy controls.
- Muscle tissue resistin expression was evaluated.
- Associations with inflammatory markers (CRP, myoglobin, creatine kinase) and disease activity scores (MYOACT) were examined.
- Resistin's effect on cytokine production in mononuclear cells and myocytes was assessed.
Main Results:
- Serum resistin levels were significantly higher in IIM patients (8.53 ± 6.84 ng/ml) compared to controls (4.54 ± 1.08 ng/ml).
- Resistin levels correlated with C-reactive protein (CRP), myositis disease activity assessment visual analogue scales (MYOACT), and creatine kinase.
- Increased resistin expression was found in muscle tissue of IIM patients, and resistin stimulated pro-inflammatory cytokine (IL-1β, IL-6, MCP-1) production in mononuclear cells.
Conclusions:
- Elevated serum resistin and muscle resistin expression are associated with inflammation and disease activity in IIM, particularly in anti-Jo-1 antibody-positive patients and dermatomyositis.
- Resistin's pro-inflammatory effects on mononuclear cells suggest a potential role in the pathogenesis of inflammatory myopathies.
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