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Long-term outcomes of patients with cerebral vein thrombosis: a multicenter study

F Dentali1, D Poli, U Scoditti

  • 1Department of Clinical Medicine, University of Insubria, Varese, Italy. fdentali@libero.it

Journal of Thrombosis and Haemostasis : JTH
|May 15, 2012
PubMed

Insights

Long-term outcomes for cerebral vein thrombosis (CVT) are generally good, with low mortality and recurrence rates. A history of venous thromboembolism (VTE) is a key predictor of future CVT events.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Thrombosis Research

Background:

  • Limited data exists on the long-term clinical outcomes following cerebral vein thrombosis (CVT).
  • Understanding long-term prognosis is crucial for patient management and risk stratification.

Purpose of the Study:

  • To evaluate long-term mortality, disability, and recurrence rates of venous thromboembolism (VTE) in patients with a first-time CVT episode.
  • To identify predictors of recurrent VTE events in this cohort.

Main Methods:

  • International, retrospective cohort study.
  • Inclusion of 706 patients with a first CVT episode.
  • Follow-up for a total of 3171 patient-years, with a median follow-up of 40 months.

Main Results:

  • Overall mortality was low at 2.8% (20 deaths).
  • Complete recovery (modified Rankin Score 0-1) was achieved by 89.1% of patients.
  • CVT recurrence occurred in 4.4% of patients, with an overall VTE recurrence incidence of 23.6 events per 1000 patient-years.

Conclusions:

  • Long-term mortality and recurrent VTE risks are low for survivors of the acute CVT phase.
  • A prior history of VTE is an independent predictor of recurrent events.
Abstract

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