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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

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Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
11:23

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry

Published on: May 22, 2012

Driving the cell cycle through metabolism.

Ling Cai1, Benjamin P Tu

  • 1Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9038, USA. benjamin.tu@utsouthwestern.edu

Annual Review of Cell and Developmental Biology
|May 15, 2012
PubMed
Summary
This summary is machine-generated.

Cell cycle entry is a metabolic process where cells assess resources to grow and divide. Understanding yeast metabolism reveals conserved mechanisms for cell growth and proliferation.

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Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
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Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

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Area of Science:

  • Cell Biology
  • Metabolic Regulation
  • Biochemistry

Background:

  • Cell cycle progression in unicellular organisms is fundamentally linked to metabolic status.
  • Cells must evaluate nutritional status and metabolic output for successful division.
  • Metabolic shifts are critical for initiating and completing the cell cycle.

Purpose of the Study:

  • To discuss metabolic changes associated with cell cycle entry and exit in Saccharomyces cerevisiae.
  • To explore how metabolism is coordinated with cell growth and proliferation.
  • To provide insights into conserved mechanisms of cell cycle control.

Main Methods:

  • Studying the unicellular eukaryote Saccharomyces cerevisiae (budding yeast).
  • Utilizing continuous, slow-growth conditions for high temporal resolution analysis.
  • Observing metabolic changes during cell cycle transitions.

Main Results:

  • Identified key metabolic alterations accompanying cell cycle entry and exit in yeast.
  • Demonstrated high temporal resolution of metabolic changes under specific growth conditions.
  • Highlighted conserved mechanisms linking metabolism to cell growth and proliferation.

Conclusions:

  • Metabolic regulation is central to cell cycle control in unicellular organisms.
  • Mechanisms coordinating metabolism and cell cycle in yeast may be conserved in multicellular life.
  • Understanding these metabolic bases can inform research on development, tumorigenesis, and growth control.