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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
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Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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Related Experiment Video

Updated: May 22, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Social jetlag and obesity.

Till Roenneberg1, Karla V Allebrandt, Martha Merrow

  • 1Institute for Medical Psychology, University of Munich, Munich, Germany. roenneberg@lmu.de

Current Biology : CB
|May 15, 2012
PubMed
Summary

Social jetlag, the mismatch between your body clock and social schedules, is linked to higher body mass index (BMI). Aligning biological and social clocks may help manage obesity.

Area of Science:

  • Chronobiology
  • Epidemiology
  • Obesity Research

Background:

  • Obesity is a major public health issue in industrialized nations.
  • Sleep duration and circadian rhythms are known factors influencing body mass index (BMI).
  • Social jetlag, a mismatch between internal circadian timing and social schedules, leads to chronic sleep loss.

Purpose of the Study:

  • To investigate the association between social jetlag and increased BMI in a large-scale epidemiological study.
  • To determine if social jetlag contributes to weight gain beyond the effects of sleep duration.

Main Methods:

  • Large-scale epidemiological study design.
  • Analysis of factors influencing body mass index (BMI).
  • Quantification of social jetlag and its correlation with BMI.

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Last Updated: May 22, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
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Published on: May 30, 2025

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
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A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

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Main Results:

  • Social jetlag is significantly associated with increased BMI, independent of sleep duration.
  • Living out of sync with one's biological clock ("against the clock") is a potential contributor to obesity.
  • Findings highlight the role of circadian rhythm disruption in weight-related pathologies.

Conclusions:

  • Social jetlag is a significant factor associated with increased BMI and obesity.
  • Aligning biological clocks with social schedules may be a strategy for obesity management.
  • Results have implications for public health policies regarding Daylight Saving Time, work, and school schedules.