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Nephrotoxicity of alternative medicine practice
1Division of Nephrology and Immunology, University of Alberta, Edmonton, Alberta, Canada. vluyckx@ualberta.ca
Advances in Chronic Kidney Disease
|May 15, 2012
Summary
Alternative medicine use can harm kidneys, causing various renal dysfunctions and even death, especially where advanced care is limited. Clinicians must report these adverse events to understand risks and potential benefits.
Area of Science:
- Nephrology
- Integrative Medicine
- Toxicology
Background:
- Alternative medicine is widely used globally, often perceived as safe due to its "natural" origin.
- The kidney's vulnerability to toxins makes it susceptible to adverse effects from alternative medicine.
- Reports indicate a range of kidney dysfunctions linked to alternative medicine, including acute kidney injury and chronic kidney disease.
Purpose of the Study:
- To review the prevalence and impact of alternative medicine use on kidney health.
- To elucidate the mechanisms of nephrotoxicity associated with alternative medicine.
- To emphasize the importance of reporting and researching adverse events related to alternative medicine.
Main Methods:
- Literature review of reported cases of kidney injury associated with alternative medicine.
- Analysis of potential mechanisms contributing to nephrotoxicity.
- Discussion of clinical implications and research needs.
Main Results:
- Alternative medicine use is linked to diverse renal dysfunctions, from electrolyte imbalances to end-stage renal disease and mortality.
- Mechanisms include direct nephrotoxicity, contamination, improper use, and drug interactions.
- High mortality rates are observed in regions lacking intensive care and dialysis.
Conclusions:
- Alternative medicine-associated nephrotoxicity is a significant clinical concern.
- Underreporting to healthcare providers is common, hindering comprehensive understanding.
- Further research and careful clinical observation are crucial to assess risks and potential benefits.
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