Longevity and age-related pathology of LVG outbred golden Syrian hamsters (Mesocricetus auratus)
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Published on: January 9, 2018
S F Deamond1, L G Portnoy, J D Strandberg
1Division of Biophysics, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.
Abstract:
A colony of male Lakeview Golden (LVG) Syrian hamsters has been maintained for the last nine years as a source of various tissues for cellular aging studies. Observations on this colony also yielded data on survival time and physical and pathological manifestations of aging in this strain. Based on 150 spontaneous deaths, the median life span was found to be 19.5 months. The maximum life span was 36 months and the minimum 6 months. A cross-sectional pathological survey of sacrificed and spontaneously dying members of the population revealed a low rate of neoplasia and a variety of degenerative lesions that increased with age. These observations of a varied pathology and a low frequency of neoplasia provide justification for the continued development of the male LVG Syrian hamster as an animal model system for use in studies on the mechanism of both in vivo and in vitro aging.
