Morphological reaction patterns of the human liver during xenobiotic loading. A light microscopic contribution

Xenobiotic load of the liver shows an increasing tendency. This can cause functional and structural lesions of this organ. Among the xenobiotic hepatotoxic agents alcohol and drugs stand in the rank order on the first position: occupational noxes follow. The liver develops different morphological patterns which reach from adaptative to alterative parenchymal changes. Inflammatory reactions of the liver mesenchyma follow which are correlated to the intensity of the parenchymal lesions. In this paper the different light microscopic patterns and the classification of such injuries are demonstrated.