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Updated: May 22, 2026
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
Published on: April 19, 2015
Nanofiber-based delivery of bioactive agents and stem cells to bone sites
Zhanpeng Zhang1, Jiang Hu, Peter X Ma
1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109-1078, USA.
Abstract:
Biodegradable nanofibers are important scaffolding materials for bone regeneration. In this paper, the basic concepts and recent advances of self-assembly, electrospinning and thermally induced phase separation techniques that are widely used to generate nanofibrous scaffolds are reviewed. In addition, surface functionalization and bioactive factor delivery within these nanofibrous scaffolds to enhance bone regeneration are also discussed. Moreover, recent progresses in applying these nanofiber-based scaffolds to deliver stem cells for bone regeneration are presented. Along with the significant advances, challenges and obstacles in the field as well as the future perspective are discussed.
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