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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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Related Experiment Video

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Isolation and Purification of Fungal &#946;-Glucan as an Immunotherapy Strategy for Glioblastoma
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Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans.

You-Kai Xu1, Shang-Gao Liao, Zhi Na

  • 1CAS Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, Yunnan Province, PR China. xyk@xtbg.ac.cn

Fitoterapia
|May 15, 2012
PubMed
Summary

Researchers isolated new Gelsemium alkaloids from Gelsemium elegans stems. These compounds, including novel ones like 21-(2-oxopropyl)-koumine, show potential as immunosuppressive agents, warranting further investigation.

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Isolation and Purification of Fungal &#946;-Glucan as an Immunotherapy Strategy for Glioblastoma
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Area of Science:

  • Natural Product Chemistry
  • Pharmacology

Background:

  • Gelsemium elegans is a plant source of bioactive alkaloids.
  • Immunosuppressive agents are crucial for treating autoimmune diseases and preventing transplant rejection.

Purpose of the Study:

  • To isolate and characterize new and known Gelsemium alkaloids from Gelsemium elegans.
  • To evaluate the isolated compounds for their immunosuppressive potential.

Main Methods:

  • Bioassay-guided fractionation of Gelsemium elegans stem extract.
  • Structure elucidation using spectroscopic methods (NMR, MS) and single-crystal X-ray diffraction.
  • In vitro evaluation of immunosuppressive activity.

Main Results:

  • Two new Gelsemium alkaloids, 21-(2-oxopropyl)-koumine (1) and 11-methoxygelselegine (2), were identified.
  • Two known alkaloids, koumine (3) and gelselegine (4), were also isolated.
  • Preliminary data suggests that Gelsemium alkaloids possess immunosuppressive properties.

Conclusions:

  • The study successfully isolated and identified novel and known Gelsemium alkaloids.
  • The findings indicate a potential therapeutic role for Gelsemium alkaloids as immunosuppressive agents.
  • Further research is needed to explore the specific mechanisms and efficacy of these compounds.