Related Experiment Video

Updated: May 22, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Epigenetic deregulation of the COX pathway in cancer

Inês Cebola1, Miguel A Peinado

  • 1Institute of Predictive and Personalized Medicine of Cancer, Badalona, Catalonia, Spain.

Progress in Lipid Research
|May 15, 2012
PubMed

Insights

Epigenetic alterations in the cyclooxygenase (COX) pathway are linked to cancer development and progression. Understanding these epigenetic changes offers new therapeutic strategies for cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Inflammation is a key driver of cancer initiation and progression.
  • The cyclooxygenase (COX) pathway is frequently dysregulated in various cancers.
  • Current treatments targeting the COX pathway have limitations due to side effects and incomplete understanding.

Purpose of the Study:

  • To review the role of epigenetic modifications in the deregulation of the COX pathway in cancer.
  • To explore the potential of targeting epigenetic alterations in the COX pathway for cancer therapy.

Main Methods:

  • Literature review of studies investigating epigenetic regulation of COX pathway genes in cancer.
  • Analysis of evidence linking aberrant gene expression in the COX pathway to epigenetic mechanisms.
  • Synthesis of current knowledge on the clinical implications of these findings.

Main Results:

  • Epigenetic alterations, rather than mutations, are frequently observed in COX pathway genes in cancer cells.
  • Aberrant gene expression of COX pathway components is a common feature across different cancer types.
  • Epigenetic dysregulation significantly contributes to the altered functionality of the COX pathway in malignancy.

Conclusions:

  • Epigenetic mechanisms are critical in controlling the COX pathway's role in cancer.
  • Targeting epigenetic alterations in the COX pathway presents a promising avenue for novel cancer therapeutics.
  • Further research into these epigenetic modifications could lead to improved clinical management strategies for cancer patients.

More Related Videos

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets03:37

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...