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Published on: June 3, 2018
Cerebrovascular accidents complicating transcatheter aortic valve implantation: frequency, timing and impact on
Stefan Stortecky1, Stephan Windecker, Thomas Pilgrim
1Department of Cardiology, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland.
Insights
Cerebrovascular accidents (CVA) after transcatheter aortic valve implantation (TAVI) occur early and significantly increase mortality. Multiple implantation attempts and chronic pulmonary disease are key predictors of CVA post-TAVI.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Interventional Cardiology
Background:
- Transcatheter aortic valve implantation (TAVI) is a critical procedure for severe aortic stenosis.
- Cerebrovascular accidents (CVA) are a significant complication following TAVI.
- Understanding CVA frequency, timing, and impact is crucial for patient outcomes.
Purpose of the Study:
- To determine the incidence and timing of CVA after TAVI.
- To assess the clinical outcomes of patients experiencing CVA within 30 days.
- To identify predictors of periprocedural CVA in TAVI patients.
Main Methods:
- Retrospective analysis of 389 high-risk patients undergoing TAVI (August 2007 - October 2011).
- Evaluation of CVA occurrence within 30 days post-procedure.
- Statistical analysis to identify independent predictors and impact on mortality.
Main Results:
- 14 patients (3.6%) experienced CVA within 30 days; 74% occurred on day one.
- CVA patients had higher all-cause (42.3% vs. 5.1%) and cardiovascular mortality (38.4% vs. 4.6%).
- Independent predictors included repeated device attempts, chronic pulmonary disease, and low BMI.
Conclusions:
- CVA after TAVI predominantly occur periprocedurally.
- CVA significantly worsen prognosis within 30 days post-TAVI.
- Identifying and mitigating risk factors like multiple implantation attempts is vital.
Aims:
Cerebrovascular accidents (CVA) are considered among the most serious adverse events after transcatheter aortic valve implantation (TAVI). The objective of the present study was to evaluate the frequency and timing of CVA after TAVI and to investigate the impact on clinical outcomes within 30 days of the procedure.
Methods And Results:
Between August 2007 and October 2011, 389 high-risk elderly patients with symptomatic severe aortic stenosis underwent TAVI via transfemoral, transapical or subclavian access. A total of 14 patients (3.6%) experienced at least one CVA within 30 days of follow-up and most events (74%) occurred within the first day of the procedure. Patients with CVA had an increased risk of all-cause (42.3% vs. 5.1%, ORadjusted 11.7, 95% CI 3.4-40.3, p<0.001) and cardiovascular mortality (38.4% vs. 4.6%, ORadjusted 10.5, 95% CI 2.9-37.8, p<0.001) compared to patients without CVA at 30 days of follow-up. Repeated device implantation attempts (ORadjusted 8.3, CI 2.1-33.3, p<0.003), chronic pulmonary disease (ORadjusted 4.7, CI 1.3-16.8, p=0.02) and body mass index <25 kg/m2 (ORadjusted 0.8, CI 0.7-0.9, p<0.01) emerged as independent predictors of periprocedural CVA.
Conclusions:
Cerebrovascular accidents among patients undergoing TAVI occur predominantly during the periprocedural period, are associated with multiple implantation attempts of the bioprosthesis and significantly impair prognosis.
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