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Published on: November 7, 2017
A hazardous link between malnutrition, inflammation and oxidative stress in renal patients
Jelena Kotur-Stevuljevic1, Sanja Simic-Ogrizovic, Violeta Dopsaj
1Institute for Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Serbia. jkotur@pharmacy.bg.ac.rs
Background:
Atherosclerosis is the main cause of mortality in end stage renal disease (ESRD) patients.
Design And Methods:
Malnutrition, inflammation and diminished paraoxonase activity were used to calculate the sum of risk factors for atherosclerosis development in a cohort of 141 chronic renal disease patients. Kaplan-Meier survival analysis was implemented to assess risk of death.
Results:
Kaplan-Meier analysis (Log rank=12.06, P=0.0072) showed higher risk of death with increasing number of risk factors in haemodialysis patients.
Conclusions:
Malnutrition in combination with inflammation and oxidative stress is associated with higher mortality in patients on long-term haemodialysis.
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