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Related Experiment Video

Updated: May 22, 2026

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Published on: December 30, 2014

Are TRP channels involved in sperm development and function?

Alberto Darszon¹, Claudia Sánchez-Cárdenas, Gerardo Orta

¹Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología-Universidad Nacional Autónoma de México, Cuernavaca, México. darszon@ibt.unam.mx

Cell and Tissue Research

|May 15, 2012

Summary

This summary is machine-generated.

Transient Receptor Potential (TRP) channels are crucial for sperm function, regulating motility, maturation, and the acrosome reaction. Understanding calcium (Ca2+) regulation via TRP channels and store-operated calcium entry (SOCE) is key for fertility research.

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Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Medium-throughput Screening Assays for Assessment of Effects on Ca²⁺-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

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Last Updated: May 22, 2026

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Published on: December 30, 2014

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Medium-throughput Screening Assays for Assessment of Effects on Ca²⁺-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

Area of Science:

Spermatozoa biology
Calcium signaling
Ion channels

Background:

Spermatozoa require precise calcium (Ca2+) signaling to interpret environmental cues and the egg for successful fertilization.
Transient Receptor Potential (TRP) channels are a family of versatile signal transducers implicated in various cellular processes.

Purpose of the Study:

To review the evidence for TRP channel presence and function in spermatozoa.
To explore the role of TRP channels in sperm motility, maturation, and the acrosome reaction.
To discuss the involvement of store-operated calcium entry (SOCE) proteins (STIM and ORAI) and their interaction with TRP channels in sperm function.

Main Methods:

Literature review of existing research on TRP channels and calcium signaling in spermatozoa.
Analysis of proposed roles for STIM and ORAI proteins in sperm function.

Main Results:

Evidence suggests TRP channels are present and actively involved in sperm motility, maturation, and the acrosome reaction.
Store-operated calcium entry (SOCE), mediated by STIM and ORAI, is proposed to be critical for these sperm functions.
Interactions between TRP channels and SOCE components are discussed as key regulatory mechanisms.

Conclusions:

TRP channels are significant players in regulating essential sperm functions through calcium signaling.
Understanding calcium regulation in spermatozoa, particularly involving TRP channels and SOCE, is vital for addressing infertility, improving animal breeding, and preserving biodiversity.