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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Subclinical cardiac abnormalities and kidney function decline: the multi-ethnic study of atherosclerosis

Meyeon Park1, Michael G Shlipak, Ronit Katz

  • 1Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94121, USA. meyeon.park@ucsf.edu

Clinical Journal of the American Society of Nephrology : CJASN
|May 15, 2012
PubMed

Insights

Subclinical cardiac abnormalities, specifically concentricity, are linked to faster kidney function decline. This association persists even when accounting for common risk factors like diabetes and hypertension.

Area of Science:

  • Cardiology
  • Nephrology
  • Cardiovascular Imaging

Background:

  • Clinical heart failure (HF) is linked to chronic kidney disease (CKD) and accelerated kidney function loss.
  • The relationship between subclinical cardiac structural abnormalities and kidney function decline is not well understood.

Purpose of the Study:

  • To evaluate the association between cardiac concentricity and kidney function decline.
  • To investigate if abnormal cardiac structure predicts faster decline in estimated glomerular filtration rate (eGFR) and incident CKD.

Main Methods:

  • Longitudinal analysis of 3866 individuals from the Multi-Ethnic Study of Atherosclerosis (2000-2007).
  • Cardiac concentricity assessed via magnetic resonance imaging.
  • Kidney function measured by estimated GFR (eGFRcr and eGFRcys); statistical models adjusted for demographics, BP, diabetes, and inflammatory markers.

Main Results:

  • Individuals in the highest quartile of cardiac concentricity experienced an additional 21% decline in mean eGFRcr compared to the lowest quartile.
  • Cardiac concentricity was significantly associated with incident CKD.
  • Higher concentricity correlated with rapid kidney function decline (>5% per year).

Conclusions:

  • Subclinical cardiac structural abnormalities are independently associated with longitudinal kidney function decline.
  • These findings highlight a potential link between cardiac health and kidney preservation, independent of common comorbidities.
  • Further research is warranted to elucidate the underlying mechanisms driving this association.
Abstract

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