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Related Concept Videos

Structural Isomerism02:34

Structural Isomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
Stereoisomerism02:52

Stereoisomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
Coordination Number and Geometry02:57

Coordination Number and Geometry

For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

New half sandwich Ru(II) coordination compounds for anticancer activity.

Ioannis Bratsos1, Elisa Mitri, Francesco Ravalico

  • 1Department of Chemical and Pharmaceutical Sciences, Via L. Giorgieri 1, 34127 Trieste, Italy.

Dalton Transactions (Cambridge, England : 2003)
|May 15, 2012
PubMed
Summary

Ruthenium(II) half sandwich complexes with new ligands show moderate antiproliferative activity against breast cancer cells. Activity depends on ligand hydrolysis rate and hydrogen bonding ability.

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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

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An In Vitro Enzymatic Assay to Measure Transcription Inhibition by Gallium(III) and H3 5,10,15-tris(pentafluorophenyl)corroles

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Last Updated: May 22, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

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An In Vitro Enzymatic Assay to Measure Transcription Inhibition by Gallium(III) and H3 5,10,15-tris(pentafluorophenyl)corroles
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Published on: March 18, 2015

Area of Science:

  • Coordination Chemistry
  • Medicinal Inorganic Chemistry

Background:

  • Ruthenium(II) half sandwich complexes are investigated for structure-activity relationships.
  • Previous studies utilized 1,4,7-trithiacyclononane ([9]aneS3) ligand.

Purpose of the Study:

  • To expand the series of Ru(II) half sandwich complexes by incorporating 1,4,7-triazacyclononane ([9]aneN3).
  • To investigate new chelating ligands (dach, pic(-), acac(-)) with both [9]aneS3 and [9]aneN3.
  • To evaluate the antiproliferative activity of these new complexes.

Main Methods:

  • Synthesis and full characterization of ten new Ru(II) half sandwich complexes.
  • Determination of chemical behavior in aqueous solution.
  • Single-crystal X-ray structure determination for eight complexes.
  • In vitro antiproliferative testing against MDA-MB-231 human mammary carcinoma cells.

Main Results:

  • Ten novel Ru(II) half sandwich complexes were successfully prepared and characterized.
  • Eight crystal structures were determined, including a versatile precursor.
  • Antiproliferative tests revealed moderate activity for compounds that hydrolyze the monodentate ligand at a reasonable rate.
  • Activity was observed only when the chelate ligand possessed hydrogen bond donor capabilities.

Conclusions:

  • The study successfully expanded the library of Ru(II) half sandwich complexes with diverse ligands.
  • Structure-activity relationships were elucidated, highlighting the importance of ligand hydrolysis and hydrogen bonding for antiproliferative effects.
  • These findings provide insights for the design of novel metallodrugs.