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Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Raynaud's phenomenon and vitamin D.

Josiane Hélou1, Roy Moutran, Ismael Maatouk

  • 1Dermatology Department, Hôtel-Dieu de France hospital, Ashrafieh, Beirut, Lebanon.

Rheumatology International
|May 15, 2012
PubMed
Summary

This study found that monthly vitamin D3 supplementation improved vitamin D levels and self-reported symptoms in patients with Raynaud

Area of Science:

  • Endocrinology
  • Immunology
  • Vascular Medicine

Background:

  • Raynaud's phenomenon (RP) lacks studies on vitamin D's effects.
  • Vitamin D deficiency is common in RP patients.
  • The potential vasodilatory role of vitamin D in RP is unexplored.

Purpose of the Study:

  • To investigate the efficacy of vitamin D3 supplementation in improving RP symptoms.
  • To assess the impact of vitamin D3 on blood vitamin D levels in RP patients.
  • To explore vitamin D's potential vasodilatory effects in RP.

Main Methods:

  • A randomized, placebo-controlled, double-blind study.
  • 53 patients with RP were recruited during winter 2010-2011.
  • 42 vitamin D-deficient patients received 600,000 IU oral vitamin D3 monthly for 8 weeks or placebo, with symptom assessment via VAS.

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Main Results:

  • Vitamin D group: average blood vitamin D increased from 20.9 to 32.9 ng/mL, with VAS scores decreasing from 58.33 to 36.2.
  • Placebo group: average blood vitamin D increased from 21.8 to 23.2 ng/mL, with VAS scores increasing from 58.33 to 64.28.
  • Significant improvement in RP symptoms and vitamin D levels observed in the vitamin D group.

Conclusions:

  • Monthly vitamin D3 supplementation effectively increases blood vitamin D levels.
  • Vitamin D3 supplementation shows a positive impact on self-reported Raynaud's phenomenon symptoms.
  • Further research is needed to confirm vitamin D's vasodilatory role in vitamin D-deficient RP patients.