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Preoperative carbohydrate loading for elective surgery: a systematic review and meta-analysis
Lun Li1, Zehao Wang, Xiangji Ying
1Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Dong Gang West Road No. 199, Lanzhou, 730000, Gansu, China. guo19880101@163.com
Surgery Today
|May 15, 2012
Summary
Preoperative oral carbohydrate (CHO) intake appears safe and may reduce postoperative insulin resistance. However, more high-quality randomized controlled trials (RCTs) are needed to confirm these findings.
Area of Science:
- Anesthesiology
- Metabolic Medicine
- Surgical Nutrition
Background:
- Preoperative oral carbohydrate (CHO) administration for elective surgery is of uncertain safety and efficacy.
- Understanding the impact of CHO on metabolic responses and adverse events is crucial for surgical patient care.
Purpose of the Study:
- To evaluate the efficacy and safety of preoperative oral carbohydrate (CHO) administration in patients undergoing elective surgery.
- To assess adverse events associated with CHO intake before surgery.
Main Methods:
- Systematic review and meta-analysis of randomized controlled trials (RCTs).
- Comprehensive literature searches were performed to identify relevant studies.
- Data extraction and quality assessment were conducted by two independent reviewers.
Main Results:
- CHO intake increased postoperative insulin and glucose levels compared to overnight fasting or IV glucose infusion.
- Compared to placebo, CHO intake led to greater insulin level declines at anesthesia induction and smaller glucose increases at surgery end.
- No aspiration events were reported in any included studies.
Conclusions:
- Preoperative oral carbohydrate (CHO) administration appears safe and may attenuate postoperative insulin resistance.
- The quality of existing evidence is generally low, necessitating larger, rigorous RCTs for definitive conclusions.
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