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Epimerization of erythromycin derivatives
1Organisch-chemisches Institut, Technische Universität München, Garching, FRG.
The Journal of Antibiotics
|October 1, 1990
Abstract:
Dirithromycin (3) isomerizes upon dissolution in different solvents. From X-ray analysis of V-T 108, an analogue of dirithromycin, and comparative 1H and 13C NMR, and MS data, the isomer of dirithromycin was confirmed to be the C-16-(S)-epimer. The ratio of the two epimers at equilibrium conditions was approximately 8:2 (R/S) in methanol at room temperature.