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Related Experiment Videos

Quinolones in perspective.

H C Neu1

  • 1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

The Journal of Antimicrobial Chemotherapy
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

Fluoroquinolones are effective against many bacteria but not anaerobes. Their overuse risks rapid development of bacterial resistance, especially in staphylococci and Pseudomonas aeruginosa.

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Area of Science:

  • Pharmacology
  • Microbiology
  • Infectious Diseases

Background:

  • Fluoroquinolones have been clinically available for five years.
  • These agents exhibit antimicrobial activity against Enterobacteriaceae, Pseudomonas aeruginosa, and staphylococci.
  • Current fluoroquinolones lack activity against streptococci and anaerobic species.

Purpose of the Study:

  • To review the pharmacological advantages of fluoroquinolones.
  • To discuss their therapeutic applications in various infections.
  • To highlight the emerging issue of antimicrobial resistance.

Main Methods:

  • Literature review of fluoroquinolone pharmacology and clinical use.
  • Analysis of antimicrobial spectrum and resistance patterns.

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  • Evaluation of therapeutic efficacy and prophylactic applications.

    • Main Results:

    • Fluoroquinolones offer significant advantages for treating urinary, respiratory, gastrointestinal, skin, soft tissue, bone, and sexually transmitted infections.
    • They are also valuable for prophylaxis in neutropenic patients.
    • A critical concern is the potential for rapid resistance development due to inappropriate use, particularly in staphylococci and P. aeruginosa.

    Conclusions:

    • Fluoroquinolones are versatile antimicrobial agents with broad-spectrum activity.
    • Judicious use is essential to preserve their efficacy and mitigate resistance.
    • Anticipating and managing fluoroquinolone resistance is crucial for future therapeutic strategies.