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Single dose pefloxacin compared with multiple dose co-trimoxazole in cystitis
E E Petersen1, F Wingen, K L Fairchild
1Universitäts-Frauenklinik, Freiburg, West Germany.
The Journal of Antimicrobial Chemotherapy
|October 1, 1990
Summary
A single dose of pefloxacin (800 mg) effectively treated acute uncomplicated cystitis in women. This treatment was found to be as safe and effective as a five-day course of co-trimoxazole.
Area of Science:
- Infectious Diseases
- Pharmacology
- Urology
Background:
- Acute uncomplicated cystitis is a common bacterial infection in women.
- Current treatment guidelines often recommend multi-day antibiotic regimens.
Purpose of the Study:
- To compare the efficacy and safety of a single-dose pefloxacin treatment versus a five-day co-trimoxazole regimen for acute uncomplicated cystitis.
- To evaluate microbiological and clinical outcomes in women treated for cystitis.
Main Methods:
- A double-blind, multicentre study involving 155 patients receiving pefloxacin and 161 receiving co-trimoxazole.
- Patients were assessed for bacteriological cure at 7-10 days and 28-42 days post-treatment.
Main Results:
- Bacteriological cure rates were high for both groups: 97.1% for pefloxacin and 95.2% for co-trimoxazole at the first follow-up.
- At the second follow-up, urine cultures were negative in 95.0% of the pefloxacin group and 90.3% of the co-trimoxazole group.
- Pefloxacin demonstrated comparable safety and efficacy to co-trimoxazole.
Conclusions:
- A single 800 mg dose of pefloxacin is a safe and effective alternative for treating acute uncomplicated cystitis in women.
- Single-dose pefloxacin offers a potentially more convenient treatment option compared to multi-day regimens.