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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
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Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Published on: August 9, 2024

Equine subepithelial keratomycosis.

Dennis E Brooks1, Caryn E Plummer, Brendan G Mangan

  • 1Departments of Large and Small Animal Clinical Sciences, University of Florida, Gainesville, Florida, USA. brooksd@ufl.edu

Veterinary Ophthalmology
|May 16, 2012
PubMed
Summary
This summary is machine-generated.

Subepithelial keratomycosis (SEK) in horses presents as subtle subepithelial opacification without iridocyclitis. Most cases resolved with topical antifungal treatment, though some recurred or progressed.

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Area of Science:

  • Veterinary Ophthalmology
  • Equine Medicine
  • Mycology

Background:

  • Equine keratomycosis encompasses various fungal infections affecting the cornea.
  • Subepithelial keratomycosis (SEK) is a less commonly described form.
  • Understanding SEK's clinical presentation is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To characterize the clinical findings, diagnostic methods, and treatment outcomes of subepithelial keratomycosis in horses.
  • To differentiate SEK from other forms of equine keratomycosis.

Main Methods:

  • Retrospective study of medical records from 2007-2011 at the University of Florida Veterinary Medical Center.
  • Inclusion criteria: horses diagnosed with subepithelial keratomycosis (SEK).
  • Data collected: signalment, clinical signs, diagnostic tests, and therapeutic responses.

Main Results:

  • Twenty-one horses with SEK were identified across various breeds.
  • All affected eyes exhibited multifocal subepithelial opacification; 16 showed weak dye uptake.
  • No iridocyclitis was observed. Fungal cytology confirmed in 10 cases; Candida and Aspergillus were cultured.
  • Topical antifungal therapy led to resolution in 19 of 21 eyes, with two recurrences and two progressions to ulcerative keratomycosis.

Conclusions:

  • Subepithelial keratomycosis (SEK) represents a distinct, subtle clinical presentation in horses.
  • SEK may be a unique entity or part of a spectrum of equine keratomycosis.
  • Early diagnosis and treatment with topical antifungals are effective for most SEK cases.