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Naturally occurring himachalenes to benzocycloheptene amino vinyl bromide derivatives: as antidepressant molecules
Abha Chaudhary1, Pralay Das, Awanish Mishra
1Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India.
Abstract:
A new series of benzocycloheptene amino vinyl bromide derivatives (9a-9m) were synthesized from isomeric mixture of himachalenes through two-step synthesis. The unusual structure of benzocycloheptene amino vinyl bromide derivative (9a) was confirmed by NMR and X-ray crystallography analyses. The newly synthesized amino vinyl bromide derivatives of benzocycloheptene were further evaluated for their antidepressant activities. The compound 9c had shown significant reduction in the immobility period.
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