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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Related Experiment Video

Updated: May 22, 2026

Small Bowel Transplantation In Mice
36:30

Small Bowel Transplantation In Mice

Published on: August 20, 2007

Stool transplants: ready for prime time?

Jeffrey S Weissman1, Walter Coyle

  • 1Division of Gastroenterology, Scripps Clinic Torrey Pines, La Jolla, CA 92037, USA. Jeffrey.Weissman@gmail.com

Current Gastroenterology Reports
|May 16, 2012
PubMed
Summary
This summary is machine-generated.

Clostridium difficile infection (CDI), a common cause of diarrhea, can be treated effectively with fecal microbiota transplantation. This study provides a detailed protocol for stool transplantation to manage recurrent CDI.

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Related Experiment Videos

Last Updated: May 22, 2026

Small Bowel Transplantation In Mice
36:30

Small Bowel Transplantation In Mice

Published on: August 20, 2007

Orthotopic Small Bowel Transplantation in Rats
09:16

Orthotopic Small Bowel Transplantation in Rats

Published on: November 6, 2012

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Area of Science:

  • Microbiology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Clostridium difficile infection (CDI) is a significant cause of antibiotic-associated diarrhea and healthcare-related infections.
  • While traditional risk factors include antimicrobial use and healthcare exposure, CDI is increasingly observed in individuals without these predispositions.
  • The gut microbiome's role in CDI pathophysiology is recognized, making microbiome restoration a therapeutic target.

Purpose of the Study:

  • To present a standardized protocol for fecal microbiota transplantation (FMT) for the management of recurrent CDI.
  • To highlight FMT as a safe and effective therapeutic option for patients with recurrent CDI.

Main Methods:

  • The study outlines a detailed protocol for stool transplantation, encompassing donor screening, stool processing, and administration methods.
  • The protocol is designed for the safe and effective implementation of FMT in a clinical setting.

Main Results:

  • Fecal microbiota transplantation has demonstrated significant safety and efficacy in managing recurrent CDI.
  • Restoration of a healthy gut microbiome through FMT is a key mechanism for CDI treatment.

Conclusions:

  • Fecal microbiota transplantation is a viable and effective treatment strategy for recurrent Clostridium difficile infection.
  • The provided protocol facilitates the standardized and safe application of stool transplantation for CDI management.