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The 14-3-3σ tumor suppressor has multiple functions in ErbB2-induced breast cancer
Nancy E Hynes1, Tatiana Smirnova
1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland. nancy.hynes@fmi.ch
Cancer Discovery
|May 16, 2012
Abstract:
Ling and colleagues demonstrated that loss of the conditional 14-3-3σ allele results in accelerated HER2/ERBB2-driven mammary tumorigenesis and metastasis. This study underscores the role of 14-3-3σ as a potent tumor suppressor in ERBB2-driven tumor initiation and progression.
