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A study on in-line tablet coating--the influence of compaction and coating on tablet dimensional changes
1GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore, Singapore, 117543.
AAPS Pharmscitech
|May 16, 2012
Summary
In-line tablet coating is feasible, with the Supercell™ coater showing suitability. Tapered dies reduce dimensional changes during immediate coating, especially with pan coaters, improving manufacturing efficiency.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Tablets require storage post-compaction for strain recovery to prevent coating defects.
- In-line coating, applying coating immediately after compaction, promises improved manufacturing efficiencies.
Purpose of the Study:
- To evaluate the feasibility of in-line tablet coating.
- To assess the influence of compaction and coating on tablet dimensional changes.
- To investigate the role of tapered dies in tablet compaction and coating.
Main Methods:
- Comparison of Supercell™ coater and pan coater for in-line coating.
- Real-time measurement of tablet dimensional changes using optical laser sensors.
- Evaluation of tablet dimensional changes after compaction and coating under controlled conditions.
Main Results:
- Compaction-induced dimensional changes were anisotropic; coating resulted in isotropic volume expansion.
- Pan coating caused greater dimensional changes than Supercell™ coating.
- Supercell™ coating showed no significant difference between in-line and delayed coating; pan coating did.
Conclusions:
- The Supercell™ coater is more suitable for in-line tablet coating.
- Tapered dies reduce dimensional changes in pan coating for in-line applications.
- In-line coating is viable, with specific equipment and process modifications enhancing its applicability.
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