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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: May 22, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Cancer cachexia and anabolic interventions: a case report.

Edgar L Dillon1, Gurjot Basra, Astrid M Horstman

  • 1Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, 77555-0569, USA.

Journal of Cachexia, Sarcopenia and Muscle
|May 16, 2012
PubMed
Summary
This summary is machine-generated.

Supplemental anabolic therapy with amino acids and testosterone improved body composition, physical function, and quality of life in a patient with recurrent cervical cancer undergoing chemotherapy. This intervention may combat cancer cachexia despite inflammatory changes.

Related Experiment Videos

Last Updated: May 22, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Area of Science:

  • Oncology
  • Metabolic Medicine
  • Nutritional Science

Background:

  • Standard-of-care (SOC) cancer treatments focus on tumor reduction but often neglect cancer cachexia.
  • Anabolic interventions like testosterone and amino acid supplements show promise for mitigating muscle wasting in cancer patients.
  • There is a need for effective supplemental therapies to manage cachexia alongside SOC treatments.

Purpose of the Study:

  • To evaluate the efficacy of combined whey protein and testosterone enanthate as an anabolic intervention in a patient with recurrent cervical cancer receiving chemotherapy.
  • To assess the impact of this intervention on body composition, inflammatory markers, muscle protein turnover, physical function, fatigue, and quality of life.

Main Methods:

  • A pilot study involving a single patient with recurrent cervical cancer undergoing cisplatin and topotecan chemotherapy.
  • The patient received daily whey protein (30g total) and weekly testosterone enanthate (100mg) injections before and during chemotherapy.
  • Comprehensive assessments included body composition, inflammatory markers, muscle protein synthesis/breakdown, physical function, fatigue, and quality of life.

Main Results:

  • Significant improvements in body composition, including increased body weight and lean body mass, and reduced fat mass.
  • Enhancements in physical function, reduced fatigue, and improved quality of life were observed.
  • Despite these benefits, inflammatory markers generally increased, and muscle protein turnover showed no improvement by the study's end.

Conclusions:

  • Concomitant administration of amino acids (whey protein) and testosterone may be a viable strategy to combat cancer cachexia and improve patient outcomes during chemotherapy.
  • This therapeutic approach can enhance body composition and quality of life, even in the presence of elevated inflammatory markers.
  • The findings suggest potential long-term benefits for managing cachexia and related symptoms in cancer patients.