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Border disease: persistant infection with the virus.

H A Westbury, D V Napthine, E Straube

    The Veterinary Record
    |May 5, 1979
    PubMed
    Summary
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    Persistent border disease virus infection in sheep can lead to affected lambs. One infected sheep showed delayed antibody production, highlighting the epidemiological significance of persistent viral infections in livestock.

    Area of Science:

    • Veterinary Virology
    • Sheep Disease Research
    • Infectious Disease Epidemiology

    Background:

    • Border disease is a significant disease in sheep flocks.
    • Persistent viral infections can pose challenges in disease control.
    • Bovine virus diarrhoea virus (BVDV) is antigenically related to the causative agent of border disease.

    Purpose of the Study:

    • To identify and characterize persistently infected sheep with border disease virus.
    • To investigate the antibody response in persistently infected sheep.
    • To discuss the epidemiological implications of persistent border disease virus infections.

    Main Methods:

    • Genetic analysis of sheep.
    • Virus isolation and antigen detection.
    • Serum antibody level testing over time.

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    Main Results:

    • Two genetically related sheep were identified with persistent border disease virus infection.
    • Some progeny of these sheep were also infected.
    • Only one infected sheep developed detectable antibodies 12 months post-infection.

    Conclusions:

    • Persistent infection with border disease virus in sheep is possible.
    • Delayed or absent antibody response can occur in persistently infected animals.
    • Persistently infected sheep may play a crucial role in disease transmission and epidemiology.