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Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

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Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...

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Related Experiment Video

Updated: May 22, 2026

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes

Published on: November 21, 2017

New roles opined for OPCML.

Sherry Y Wu¹, Anil K Sood

¹Department of Gynecologic Oncology, Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Cancer Discovery

|May 16, 2012

Summary

The OPCML gene, often lost in ovarian tumors, fights cancer by targeting oncogenic receptor tyrosine kinases (RTKs). This interaction inhibits tumor cell growth, offering a potential therapeutic strategy.

Area of Science:

Oncology
Molecular Biology
Cancer Genetics

Background:

Ovarian cancer is a significant health concern with limited effective treatments.
The OPCML gene is frequently inactivated in ovarian tumors, suggesting a tumor suppressor role.
Receptor tyrosine kinases (RTKs) are crucial in driving tumor growth and are often dysregulated in cancer.

Purpose of the Study:

To investigate the mechanism by which OPCML exerts its antitumor effects.
To determine the interaction between OPCML and oncogenic RTKs.
To assess the potential of targeting RTKs via OPCML for ovarian cancer therapy.

Main Methods:

In vitro assays to study protein-protein interactions.
Cell-based experiments to analyze gene expression and cell proliferation.

Related Experiment Videos

Last Updated: May 22, 2026

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes

Published on: November 21, 2017

Tumor xenograft models to evaluate in vivo efficacy.

Main Results:

OPCML binds to the extracellular domains of several oncogenic RTKs.
This binding leads to the downregulation of RTK signaling in tumor cells.
OPCML-mediated RTK downregulation significantly inhibits tumor growth in preclinical models.

Conclusions:

OPCML functions as a tumor suppressor in ovarian cancer by inhibiting RTK signaling.
Targeting RTKs through OPCML represents a promising therapeutic strategy for ovarian cancer.
Further research into OPCML-based therapies could lead to novel ovarian cancer treatments.