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Updated: May 22, 2026

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes
05:48

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes

Published on: November 21, 2017

New roles opined for OPCML

Sherry Y Wu1, Anil K Sood

  • 1Department of Gynecologic Oncology, Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Cancer Discovery
|May 16, 2012
PubMed

Insights

The OPCML gene, often lost in ovarian tumors, fights cancer by targeting oncogenic receptor tyrosine kinases (RTKs). This interaction inhibits tumor cell growth, offering a potential therapeutic strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • Ovarian cancer is a significant health concern with limited effective treatments.
  • The OPCML gene is frequently inactivated in ovarian tumors, suggesting a tumor suppressor role.
  • Receptor tyrosine kinases (RTKs) are crucial in driving tumor growth and are often dysregulated in cancer.

Purpose of the Study:

  • To investigate the mechanism by which OPCML exerts its antitumor effects.
  • To determine the interaction between OPCML and oncogenic RTKs.
  • To assess the potential of targeting RTKs via OPCML for ovarian cancer therapy.

Main Methods:

  • In vitro assays to study protein-protein interactions.
  • Cell-based experiments to analyze gene expression and cell proliferation.
  • Tumor xenograft models to evaluate in vivo efficacy.

Main Results:

  • OPCML binds to the extracellular domains of several oncogenic RTKs.
  • This binding leads to the downregulation of RTK signaling in tumor cells.
  • OPCML-mediated RTK downregulation significantly inhibits tumor growth in preclinical models.

Conclusions:

  • OPCML functions as a tumor suppressor in ovarian cancer by inhibiting RTK signaling.
  • Targeting RTKs through OPCML represents a promising therapeutic strategy for ovarian cancer.
  • Further research into OPCML-based therapies could lead to novel ovarian cancer treatments.

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