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Updated: May 22, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Spontaneously occurring multicentric basal cell carcinoma and keratoacanthomas in a multimammate mouse (Mastomys
Maja Eydner1, Björn Jacobsen, Martina Thomann
1Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany. Maja.Eydner@tiho-hannover.de
Abstract:
A multicentric basal cell carcinoma was diagnosed in a male multimammate mouse (Mastomys spp.) with widespread cutaneous alterations. Macroscopically, the skin was thickened and extremely wrinkled. Histopathological examination showed multicentric expanding cell-rich tumors composed of basaloid cells interpreted as basal cell carcinoma. Immunohistochemistry detected strong cytokeratin 14 positivity in the epidermal basal layer and in loosely arranged areas of these tumors but only a minimal positive reaction in densely packed areas of tumor cells. Furthermore, samples from the abdomen showed 3 nodular proliferations diagnosed as keratoacanthomas.

