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Published on: August 26, 2009
Formation of nano-bio-complex as nanomaterials dispersed in a biological solution for understanding nanobiological
Mingsheng Xu1, Jie Li, Hideo Iwai
1State Key Laboratory of Silicon Materials, MOE Key Laboratory of Macromolecule Synthesis and Functionalization & Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. msxu@zju.edu.cn
Abstract:
Information on how cells interface with nanomaterials in biological environments has important implications for the practice of nanomedicine and safety consideration of nanomaterials. However, our current understanding of nanobiological interactions is still very limited. Here, we report the direct observation of nanomaterial bio-complex formation (other than protein corona) from nanomaterials dispersed in biologically relevant solutions. We observed highly selective binding of the components of cell culture medium and phosphate buffered saline to ZnO and CuO nanoparticles, independent of protein molecules. Our discoveries may provide new insights into the understanding of how cells interact with nanomaterials.
