Related Experiment Video

Updated: May 22, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

Parallel anticancer drug development and molecular stratification to qualify predictive biomarkers: dealing with

Victor Moreno Garcia1, Philippe A Cassier, Johann de Bono

  • 1Drug Development Unit, The Royal Marsden National Health Service Foundation Trust, Sutton, Surrey, United Kingdom.

Cancer Discovery
|May 16, 2012
PubMed

Insights

Anticancer drug development is slow and costly. This study proposes a parallel process for predictive biomarker and drug development to improve efficiency and reduce risks in clinical trials.

Area of Science:

  • Oncology
  • Pharmacology
  • Biomarker Discovery

Background:

  • Current anticancer drug development models are inefficient, costly, and prone to late-stage failures.
  • The traditional approach, developed decades ago for chemotherapy, struggles with modern targeted therapies.
  • High attrition rates in late-stage clinical trials represent a significant financial and temporal burden.

Purpose of the Study:

  • To address the inefficiencies and high risks in current anticancer drug development.
  • To propose a novel, more efficient parallel process for developing predictive biomarkers and anticancer drugs concurrently.
  • To overcome obstacles hindering progress in molecularly targeted drug development.

Main Methods:

  • Incorporating a Pharmacologic Audit Trail with pharmacokinetic and pharmacodynamic data.
  • Utilizing molecular biomarker-based patient selection in early clinical trials.
  • Leveraging novel technologies like next-generation sequencing and circulating tumor-cell isolation.

Main Results:

  • The proposed parallel process aims to accelerate the qualification of predictive biomarkers.
  • It seeks to reduce the costs and time associated with developing certified clinical assays.
  • This approach is designed to mitigate the risks of late drug attrition.

Conclusions:

  • A parallel development process for predictive biomarkers and anticancer drugs is essential for modern oncology.
  • This strategy can enhance the efficiency and success rate of bringing targeted therapies to patients.
  • Addressing concerns about cost and time is critical for implementing biomarker-driven clinical trials.

More Related Videos

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis07:40

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Published on: March 20, 2021

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...