[Systemic and organ mechanisms of the organism oxygen supply in high altitude]

Organ and systemic mechanisms of organism oxygen supply in adaptation to high altitude of the Tien Shan (3200 m above sea level) were studied in the experiments on dogs. It is shown that in the first few days in the mountains (5-7th and 15th days) oxygen supply of the body is due to the increased delivery of O2 to organs and tissues; in the process of adaptation (30 days), the efficiency of tissue utilization of O2 increases. Changes of organ blood flow in visceral and somatic organs, features of compensation of the tissue hypoxia and oxygen supply of the heart, brain, skeletal muscle in different periods of adaptation to high altitude were established.