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A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
05:35

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

Published on: January 19, 2024

Anaemia treatment in chronically dialysed children: a multicentre nationwide observational study

Anna Jander1, Ryszard Wierciński, Irena Bałasz-Chmielewska

  • 1Nephrology Division, Department of Paediatrics and Immunology with Nephrology Division, Polish Mothers' Memorial Hospital Research Institute, Lodz, Poland. ajander@wp.pl

Scandinavian Journal of Urology and Nephrology
|May 17, 2012
PubMed

Insights

Treatment with erythropoiesis-stimulating agents (ESAs) for anaemia in children with chronic kidney disease in Poland is often unsatisfactory. Factors like late treatment initiation, inadequate dosing, malnutrition, and infections contribute to poor outcomes.

Area of Science:

  • Pediatric Nephrology
  • Hematology
  • Pharmacotherapy

Background:

  • Erythropoiesis-stimulating agents (ESAs) are standard for treating anaemia in children with chronic kidney disease (CKD).
  • Understanding ESA treatment efficacy in pediatric dialysis patients is crucial for optimizing care.

Purpose of the Study:

  • To evaluate the efficacy and treatment details of ESAs in Polish children undergoing dialysis.
  • To identify factors influencing anaemia treatment outcomes in this population.

Main Methods:

  • Prospective observational study across 12 Polish dialysis centers.
  • Involved 117 children with a mean age of approximately 13.75 years.
  • Data collected on ESA type, dosage, hemoglobin levels, and patient characteristics.

Main Results:

  • Epoietin beta and darbepoietin were commonly used ESAs.
  • Mean ESA dose varied significantly between peritoneal dialysis and hemodialysis.
  • Anaemia treatment was unsatisfactory in 52% of subjects.
  • Predictors of poor outcomes included low initial hemoglobin, infection, younger age at dialysis initiation, malnutrition, and inadequate ESA dosage.

Conclusions:

  • Anaemia management in Polish pediatric dialysis patients is suboptimal.
  • Late treatment initiation, insufficient dosing, malnutrition, and infections are significant risk factors for treatment failure.
Abstract

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