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CONCERN: Does ovary need D-chiro-inositol?
Rosalbino Isabella1, Emanuela Raffone
1C,I,S, Reproductive Medicine, Lamezia Terme, Italy. rosalbinoisabella@gmail.com.
Journal of Ovarian Research
|May 17, 2012
Summary
High doses of D-chiro-inositol (DCI) negatively impact ovarian response and oocyte quality in women with Polycystic Ovary Syndrome (PCOS). This study suggests DCI may not be beneficial for PCOS patients undergoing fertility treatments.
Area of Science:
- Reproductive endocrinology
- Gynecology
- Metabolic disorders
Background:
- Polycystic Ovary Syndrome (PCOS) affects 10% of reproductive-aged women, causing infertility.
- PCOS is linked to insulin resistance (IR), with inositol isomers explored as therapeutic agents.
- Previous studies show mixed results for D-chiro-inositol (DCI) in PCOS, unlike myo-inositol.
Purpose of the Study:
- To investigate the specific role of D-chiro-inositol (DCI) at the ovarian level in women with PCOS.
- To evaluate the dose-dependent effects of DCI on ovarian response and oocyte quality.
Main Methods:
- 54 women diagnosed with PCOS (aged <40) were enrolled, excluding those with IR or hyperglycemia.
- Participants were randomized into 5 groups: placebo and 4 groups receiving daily DCI doses (300-2400 mg) for 8 weeks.
- Treatments preceded follicle-stimulating hormone (rFSH) administration.
Main Results:
- Higher DCI doses significantly increased total r-FSH units required.
- Immature oocyte numbers rose with higher DCI doses, while MII oocytes decreased.
- DCI supplementation significantly reduced the number of grade I embryos.
Conclusions:
- Increasing DCI dosage progressively worsens oocyte quality in PCOS patients.
- Ovarian response is negatively impacted by higher DCI doses.
- DCI may have detrimental effects on reproductive outcomes in PCOS.
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