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Related Concept Videos

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein and Protein Structures02:15

Protein and Protein Structures

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Principles, challenges and advances in ab initio protein structure prediction.

Arunachalam Jothi1

  • 1Department of Bioinformatics, SCBT, SASTRA University, Thanjavur, India. arunachalam@bioinfo.sastra.edu

Protein and Peptide Letters
|May 17, 2012
PubMed
Summary

Computational methods are essential for predicting protein structures due to the growing sequence-structure gap. Ab initio protein structure prediction, using sequence data alone, is crucial for proteins lacking known structural homologs.

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Area of Science:

  • Structural biology
  • Computational biology
  • Biophysics

Background:

  • The number of known protein sequences vastly exceeds experimentally determined structures.
  • Experimental structure determination methods cannot keep pace with sequence data generation.
  • Computational approaches are vital to bridge the protein sequence-structure gap.

Purpose of the Study:

  • To review the principles, complexities, challenges, and recent advancements in ab initio protein structure prediction.
  • To highlight the necessity of ab initio methods for proteins without detectable sequence homology to known structures.

Main Methods:

  • Template-based modeling for proteins with known structural homologs.
  • Ab initio methods for proteins lacking detectable sequence relationships to known structures.
  • Utilizing thermodynamic principles to identify the native protein structure as the global minimum of an energy landscape.

Main Results:

  • Significant progress has been made in developing ab initio protein structure prediction methods.
  • Ab initio methods aim to predict protein structure solely from sequence information.
  • These methods are computationally intensive and present considerable challenges.

Conclusions:

  • Ab initio protein structure prediction is a critical area of computational biology.
  • Continued development is necessary to overcome the inherent complexities and challenges.
  • These methods are indispensable for understanding the proteome in the absence of experimental structures.