Adherence issues in pediatric bone marrow transplantation

The procedure of bone marrow transplantation entails a prolonged, aversive regimen in which adherence problems often develop, particularly with administration of oral antibiotic medications. A retrospective chart review revealed that 52% of pediatric patients evidenced significant adherence problems during the procedure. The highest rates of noncompliance were found in preschool and school-age children, with a surprisingly lower frequency in adolescents. Case summaries are presented to illustrate significant clinical issues and intervention strategies. These are discussed in terms of both their practical and theoretical significance regarding the determinants of adherence behavior.