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Updated: May 22, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Otolaryngologic manifestations of craniofacial syndromes
Laura H Swibel Rosenthal1, Nadieska Caballero, Amelia F Drake
1Division of Neurosciences, Department of Otolaryngology - Head and Neck Surgery, Stritch School of Medicine, Loyola University Hospital, 2160 South First Avenue, Maywood, IL 60153-5500, USA. LHRosenthal@lumc.edu
Abstract:
This review describes important aspects of the most commonly encountered craniofacial syndromes. The goal is to provide otolaryngologists and other health care providers with critical information necessary to manage these patients appropriately. The algorithm provided in this article should be helpful in guiding the treatment of craniofacial patients based on their unique otolaryngologic characteristics. The principles highlighted in the algorithm can be applied to other craniofacial syndromes not addressed here, including Pierre Robin sequence and Down syndrome.
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