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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Related Experiment Video

Updated: May 22, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Recurrent respiratory papillomatosis.

Naren N Venkatesan1, Harold S Pine, Michael P Underbrink

  • 1Department of Otolaryngology, University of Texas Medical Branch, 7.104 John Sealy Annex, 301 University Boulevard, Galveston, TX 77555-0521, USA.

Otolaryngologic Clinics of North America
|May 17, 2012
PubMed
Summary

Recurrent respiratory papillomatosis (RRP), a rare HPV-related disease, currently lacks a cure. Management involves surgical removal of papillomas, with the role of HPV vaccines in RRP prevention remaining unclear.

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Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Oncology

Background:

  • Recurrent respiratory papillomatosis (RRP) is a rare, benign neoplastic disease affecting the upper aerodigestive tract.
  • RRP pathogenesis is linked to human papillomavirus (HPV) infection, typically transmitted during birth.
  • Current management strategies for RRP primarily involve surgical debulking of papillomatous lesions.

Purpose of the Study:

  • To review the current understanding of RRP, including its etiology, clinical presentation, and management.
  • To discuss the potential, yet undetermined, role of HPV vaccination in RRP prevention.
  • To highlight the challenges in managing this rare and incurable condition.

Main Methods:

  • Literature review of RRP etiology, transmission, and clinical course.
  • Analysis of current therapeutic approaches, including surgical and adjuvant treatments.
  • Exploration of the epidemiological link between HPV infection and RRP development.

Main Results:

  • RRP is caused by HPV, with transmission often occurring vertically from mother to child.
  • Clinical symptoms of RRP can be subtle and variable.
  • The efficacy of HPV vaccines in preventing RRP is not yet established.

Conclusions:

  • RRP remains a challenging disease with no definitive cure.
  • Further research is needed to explore the potential of HPV vaccines in RRP prophylaxis.
  • Multidisciplinary management is essential for patients with recurrent respiratory papillomatosis.