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Published on: March 20, 2017
Inflammatory markers and bariatric surgery: a meta-analysis
1Department of Surgery, New York University School of Medicine, New York, NY 10016, USA. ragha1234@yahoo.com
Summary
Bariatric surgery significantly reduces C-reactive protein (CRP) and interleukin (IL)-6 levels, indicating a decrease in obesity-related inflammation. Tumor necrosis factor-alpha (TNFα) changes require further investigation with randomized trials.
Area of Science:
- Metabolic and Bariatric Surgery
- Inflammation and Immunology
- Obesity Research
Background:
- Obesity is characterized by chronic low-grade inflammation, with elevated inflammatory markers like C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor-alpha (TNFα).
- Previous studies show inconsistent changes in these inflammatory markers following bariatric surgery.
Purpose of the Study:
- To confirm the impact of bariatric surgery on blood levels of CRP, IL-6, and TNFα.
- To provide a consolidated analysis of inflammatory marker changes post-bariatric surgery.
Main Methods:
- A systematic literature search was conducted on Pubmed and EMBASE databases.
- Meta-analysis was performed on observational studies measuring CRP, IL-6, and TNFα before and after bariatric surgery, analyzing data at maximum and discrete follow-up times.
Main Results:
- Bariatric surgery led to a significant reduction in CRP by approximately 66% and IL-6 by 27%.
- No statistically significant change was observed in TNFα levels after bariatric surgery.
Conclusions:
- Bariatric surgery effectively decreases low-grade inflammation associated with obesity, as evidenced by reductions in CRP and IL-6.
- Further randomized controlled trials are recommended to investigate the effects of bariatric surgery on TNFα.
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